image146

Here is a Partial List of Studies

Here are some of the studies

   

Randomized Controlled Trials

Enhanced External Counterpulsation Improves Exercise Tolerance in Patients With Chronic Heart Failure

Feldman AM, Silver MA, Francis GS, Abbottsmith CW, Fleishman BL, Soran O, de Lame PA, Varricchione T for the PEECH Investigators. Journal of the American College of Cardiology. 2006 Sep 19;48(6):1199-1206. Epub 2006 Aug 25.

Enhanced External Counterpulsation Improves Exercise Duration and Peak Oxygen Consumption in Older Patients With Heart Failure: A Subgroup Analysis of the PEECH Trial. Abbottsmith CW, Chung ES, Varricchione T, de Lame PA, Silver MA, Francis GS, Feldman AM; Prospective Evaluation of EECP in Congestive Heart Failure (PEECH) Investigators. Congestive Heart Failure. 2006 Nov-Dec;12(6):307-311.

Treating Heart Failure With Enhanced External Counterpulsation (EECP): Design of the Prospective Evaluation of EECP in Heart Failure (PEECH) Trial. Feldman AM, Silver AM, Francis GS, de Lame P, Parmley WW. Journal of Cardiac Failure. 2005 Apr;11(3):240-245.

Effects of Enhanced External Counterpulsation on Health-Related Quality of Life Continue 12 Months After Treatment: A Substudy of the Multicenter Study of Enhanced External Counterpulsation. Arora RR, Chou TM, Jain D, Fleishman B, Crawford L, McKiernan T, Nesto R, Ferrans CE, Keller S.

Journal of Investigative Medicine. 2002 Jan;50(1):25-32.

The Multicenter Study of Enhanced External Counterpulsation (MUST-EECP): Effect of EECP on Exercise-Induced Myocardial Ischemia and Anginal Episodes. Arora RR, Chou TM, Jain D, Fleishman B, Crawford L, McKiernan T, Nesto R. The Journal of the American College of Cardiology. 1999 Jun;33(7):1833-1840.


Erectile Dysfunction

Enhanced External Counterpulsation in Patients with Coronary Artery Disease-Associated Erectile Dysfunction. Part I: Effects of Risk Factors. El-Sakka A, Morsy A, Fagih B. Journal of Sexual Medicine. 2007 May;4(3):771-779. Epub 2007 Apr 13.

Enhanced External Counterpulsation In Patients With Coronary Artery Disease-Associated Erectile Dysfunction. Part II: Impact Of Disease Duration And Treatment Courses. El-Sakka AI, Morsy AM, Fagih BI. The Journal of Sexual Medicine. 2007 Jul 18;4(5):448–1453. [Epub ahead of print].

Effect of Enhanced External Counterpulsation on Medically Refractory Angina Patients with Erectile Dysfunction. Lawson WE, Hui JC, Kennard ED, Soran O, McCullough PA, Kelsey SF; for the IEPR Investigators. International Journal of Clinical Practice. 2007 May;61(5):757-762.

Enhanced External Counterpulsation as a New Treatment Modality for Patients with Erectile Dysfunction. Froschermaier SE, Werner D, Leike S, Schneider M, Waltenberger J, Daniel WG, Wirth MP.

Urologia Internationalis. 1998;61(3):168-171.

International EECP Patient Registries

Refractory angina

Enhanced External Counterpulsation in the Treatment of Chronic Refractory Angina: A Long-term Follow- up Outcome from the International Enhanced External Counterpulsation Patient Registry. Loh PH, Cleland JG, Louis AA, Kennard ED, Cook JF, Caplin JL, Barsness GW, Lawson WE, Soran OZ, Michaels AD. Clinical Cardiology. 2008 Apr 10;31(4):159-164.

Residual High-Grade Angina After Enhanced External Counterpulsation Therapy. McCullough PA, Henry TD, Kennard ED, Kelsey SF, Michaels AD; IEPR Investigators. Cardiovascular Revascularization Medicine: Including Molecular Interventions. 2007 Jul-Sep;8(3):161-165.

Effectiveness of Repeat Enhanced External Counterpulsation for Refractory Angina in Patients Failing to Complete an Initial Course of Therapy. Lawson WE, Barsness G, Michaels AD, Soran O, Kennard ED, Kelsey SF, Hui JCK. Cardiology. 2006 Nov 1;108(3):170-175 [Epub ahead of print]

Two-Year Outcomes in Patients with Mild Refractory Angina Treated with Enhanced External Counterpulsation. Lawson WE, Hui JCK, Kennard ED, Kelsey SF, Michaels AD, Soran O. Clinical Cardiology. 2006 Feb;29(2):69-73.

Predictors of Benefit in Angina Patients One Year After Completing Enhanced External Counterpulsation: Initial Responders to Treatment Versus Nonresponders. Lawson WE, Hui JCK, Kennard ED, Barsness G, Kelsey SF. Cardiology. 2005 Apr 13;103(4):201-206.

   

Frequency and Efficacy of Repeat Enhanced External Counterpulsation for Stable Angina Pectoris (from the International EECP Patient Registry). Michaels AD, Barsness GW, Soran O, Kelsey SF, Kennard ED, Hui JCK, and Lawson WE for the International EECP Patient Registry Investigators. American Journal of Cardiology. 2005 Feb;95(3):394-397.

Effectiveness of Enhanced External Counterpulsation in Patients with Left Main Disease and Angina Lawson WE, Hui JCK, Barsness GW, Kennard ED, Kelsey SF for the IEPR Investigators. Clinical Cardiology. 2004 Aug;27(8):459-463.

Enhanced External Counterpulsation as Initial Revascularization Treatment for Angina Refractory to Medical Therapy. Fitzgerald CP, Lawson WE, Hui JC, Kennard ED; IEPR Investigators. Cardiology. 2003 Nov;100(3):129-135.

Enhanced External Counterpulsation for the Relief of Angina in Patients with Diabetes: Safety, Efficacy and 1-Year Clinical Outcomes. Linnemeier G, Rutter MK, Barsness G, Kennard ED, Nesto RW; IEPR Investigators. American Heart Journal. 2003 Sep;146(3):453-458.

Analysis of Baseline Factors Associated with Reduction in Chest Pain in Patients with Angina Pectoris Treated by Enhanced External Counterpulsation. Lawson WE, Kennard ED, Hui JCK, Holubkov R, Kelsey SF. American Journal of Cardiology. 2003 Aug 15;92(4):439-443.

Enhanced External Counterpulsation in the Management of Angina in the Elderly. Linnemeier G, Michaels AD, Soran O, Kennard ED; International EECP Registry (IEPR) Investigators.

American Journal of Geriatric Cardiology. 2003 Mar-Apr;12(2):90-96.

Relation of the Pattern of Diastolic Augmentation During a Course of Enhanced External Counterpulsation (EECP) to Clinical Benefit [from the International EECP Patient Registry (IEPR)]. Lakshmi MV, Kennard ED, Kelsey SF, Holubkov R, Michaels AD. American Journal of Cardiology. 2002 Jun 1;89(11):1303-1305.

The International EECP Patient Registry (IEPR): Design, Methods, Baseline Characteristics

and Acute Results. Barsness G, Feldman AM, Holmes Jr. DR, Holubkov R, Kelsey SF, Kennard ED.

Clinical Cardiology. 2001 Jun;24(6):435-442.

Does Higher Diastolic Augmentation Predict Clinical Benefit from Enhanced External Counterpulsation?: Data from the International EECP Patient Registry (IEPR). Michaels AD, Kennard ED, Kelsey SE, Holubkov R, Soran O, Spence S, Chou TM. Clinical Cardiology. 2001 Jun;24(6):453-458.

Heart Failure / Left Ventricular dysfunction

Impact of External Counterpulsation Treatment on Emergency Department Visits and Hospitalizations in Refractory Angina Patients with Left Ventricular Dysfunction. Soran O, Kennard ED, Bart BA, Kelsey SF. Congestive Heart Failure. 2007 Jan-Feb;13(1):36-40

Two-Year Clinical Outcomes After Enhanced External Counterpulsation (EECP) Therapy in Patients with Refractory Angina Pectoris and Left Ventricular Dysfunction (Report from The International EECP Patient Registry). Soran O, Kennard ED, Kfoury AG, Kelsey SF; IEPR Investigators. American Journal of Cardiology. 2006 Jan 1;97(1):17-20. Epub 2005 Nov 2.

Angina Patients with Diastolic Versus Systolic Heart Failure Demonstrate Comparable Immediate and One-Year Benefit from Enhanced External Counterpulsation. Lawson WE, Silver MA, Hui JCK, Kennard ED, Kelsey SF.Journal of Cardiac Failure. 2005 Feb;11(1):61-66.

Enhanced External Counterpulsation as Treatment for Chronic Angina in Patients with Left Ventricular Dysfunction: A Report from the International EECP Patient Registry (IEPR). Soran O, Kennard ED, Kelsey SF, Holubkov R, Strobeck J, Feldman AM. Congestive Heart Failure. 2002 Nov-Dec;8(6):297-302.

   

Benefit and Safety of Enhanced External Counterpulsation in Treating Coronary Artery Disease Patients with a History of Congestive Heart Failure. Lawson WE, Kennard ED, Holubkov R, Kelsey SF, Strobeck JE, Soran O, Feldman AM. Cardiology. 2001;96(2):78-84.

Case Serial

Refractory angina

EECP: A Non-invasive Therapy for Refractory Angina. Beaini Y, Morley C. Practitioner. 2009, Feb;253 (1715):27-31.

Enhanced External Counterpulsation in Treatment of Refractory Angina Pectoris: Two Year Outcome and Baseline Factors Associated with Treatment Failure. Erdling A, Bondesson S, Petterson T, Edvinsson L. BMC Cardiovasc Disord. 2008 Dec 18;8(1):39. [Epub ahead of print]

An Analysis of the Efficacy and Safety of Enhanced External Counterpulsation at West Virginia University Hospitals. Sajja V, Dod H, Beto R, Jain AC, Hobbs GR, Finkel MS. The West Virginia Medical Journal.

2007 May-Jun;103(3):10-12

Effects of Enhanced External Counterpulsation on Anginal Symptoms and Improvements in Objective Measures of Myocardial Ischaemia. Yavari M, Montazeri HR. Cardiovascular Journal of South Africa. 2007 May-Jun;18(3):154-156.

One Year Follow-up of Patients with Refractory Angina Pectoris Treated with Enhanced External Counterpulsation.Pettersson T, Bondesson S, Cojocaru D, Ohlsson O, Wackenfors A, Edvinsson L. BMC Cardiovascular Disorder. 2006 Jun 15;6:28.

The Immediate and Long-term Outcome of Enhanced External Counterpulsation in Treatment of Chronic Stable Refractory Angina. Loh PH, Louis AA, Wundram J, Rigby AS, Cook J, Hurren S, Nikolay NP, Caplin J, Cleland JG. Journal of Internal Medicine. 2006 Mar;259(3):276-284.

The Effects of Enhanced External Counterpulsation on Myocardial Perfusion in Patients with Stable Angina: A Multicenter Radionuclide Study. Michaels ADF, Raisinghani A, Soran O, de Lame PA, Lemaire ML, Kligfield P, Watson DD, Conti CR, Beller G. American Heart Journal. 2005 Nov;150(5):1066-1073.

Exercise Capability and Myocardial Perfusion in Chronic Angina Patients Treated with Enhanced External Counterpulsation. Tartaglia J, Stenerson Jr J, Charney R, Ramasamy S, Fleishman BL, Gerardi P, Hui JCK. Clinical Cardiology. 2003 Jun;(26):287-290.

Effects of Enhanced External Counterpulsation on Stress Radionuclide Coronary Perfusion and Exercise Capacity in Chronic Stable Angina Pectoris. Stys TP, Lawson WE, Hui JCK, Fleishman B, Manzo K, Strobeck JE, Tartaglia J, Ramasamy S, Suwita R, Zheng ZS, Liang H, Werner D. American Journal of Cardiology. 2002 Apr 1;89(7):822-824.

Enhanced External Counterpulsation Improved Myocardial Perfusion and Coronary Flow Reserve in Patients with Chronic Stable Angina; Evaluation by 13N-Ammonia Positron Emission Tomography. Masuda D, Nohara R, Hirai T, Kataoka K, Chen LG, Hosokawa R, Inubushi M, Tadamura E, Fujita M, Sasayama S. European Heart Journal. 2001 Aug;22(16):1451-1458.

Psychosocial Effects of Enhanced External Counterpulsation in the Angina Patient: A Second Study Springer S, Fife A, Lawson W, Hui JCK, Jandorf L, Cohn PF, Fricchione G. Psychosomatics. 2001 Mar- Apr;42(2):124-132.

   

Enhanced External Counterpulsation Improves Exercise Tolerance, Reduces Exercise-Induced Myocardial Ischemia and Improves Left Ventricular Diastolic Filling in Patients with Coronary Artery Disease

Urano H, Ikeda H, Ueno T, Matsumoto T, Murohara T, Imaizumi T. Journal of the American College of Cardiology. 2001 Jan;37(1):93-99.

Treatment Benefit in the Enhanced External Counterpulsation Consortium. Lawson WE, Hui JCK, Lang G. Cardiology. 2000;94(1):31-35.

Long-Term Prognosis of Patients with Angina Treated with Enhanced External Counterpulsation:

Five-Year Follow-Up Study. Lawson WE, Hui JCK, Cohn PF. Clinical Cardiology. 2000 Apr;23(4):254- 258.

Improvement of Regional Myocardial and Coronary Blood Flow Reserve in a Patient Treated with Enhanced External Counterpulsation: Evaluation by Nitrogen-13 Ammonia PET. Masuda D, Nohara R, Inada H, Hirai T, Li-Guang C, Kanda H, Inubushi M, Tadamura E, Fujita M, Sasayama S. Japanese Circulation Journal. 1999 May;63(5):407-411.

Prior Revascularization Increases the Effectiveness of Enhanced External Counterpulsation. Lawson WE, Hui JCK, Guo T, Burger L, Cohn PF. Clinical Cardiology 1998 Nov;21(11):841-844.

Maximizing the Hemodynamic Benefit of Enhanced External Counterpulsation. Suresh K, Simandl S, Lawson WE, Hui JCK, Lillis O, Burger L, Guo T, Cohn PF. Clinical Cardiology. 1998 Sep;21(9):649-653.

Psychosocial Aspects of Enhanced External Counterpulsation. Fricchione GL, Hui JCK, Fife A, Jandorf L, Vaccaro B, Burger L, Lawson WE, Cohn P. Cardiovascular Reviews and Reports. 1997 Oct;18(10):37-41.

Enhanced External Counterpulsation as an Adjunct to Revascularization in Unstable Angina. Lawson WE, Hui JCK, Oster ZH, Zheng ZS, Cabahug C, Katz JP, Dervan JP, Burger L, Jiang L, Soroff HS, Cohn PF. Clinical Cardiology. 1997 Feb;20:178-180.

Improved Exercise Tolerance Following Enhanced External Counterpulsation: Cardiac or Peripheral Effect? Lawson WE, Hui JCK, Zheng ZS, Burger L, Jiang L, Lillis O, Oster Z, Soroff H, Cohn PF. Cardiology.

1996 Jul-Aug;87(4):271-275.

Can Angiographic Findings Predict which Coronary Patients will Benefit from Enhanced External Counterpulsation? Lawson WE, Hui JCK, Zheng ZS, Burger L, Jiang L, Lillis O, Soroff HS, Cohn PF. American Journal of Cardiology. 1996 May 15;77(12):1107-1109.

Psychosocial Effects of Enhanced External Counterpulsation in the Angina Patient. Fricchione GL, Jaghab K, Lawson W, Hui JCK, Jandorf L, Zheng ZS, Cohn PF, Soroff H. Psychosomatics. 1995 Sep- Oct;36(5):494-497.

Three-Year Sustained Benefit from Enhanced External Counterpulsation in Chronic Angina Pectoris Lawson WE, Hui JCK, Zheng ZS, Oster Z, Katz JP, Diggs P, Burger L, Cohn CD, Soroff HS, Cohn PF. American Journal of Cardiology. 1995 Apr 15;75:840-841.

Efficacy of Enhanced External Counterpulsation in the Treatment of Angina Pectoris. Lawson WE, Hui JCK, Soroff HS, Zheng ZS, Kayden DS, Sasvary D, Atkins H, Cohn PF. American Journal of Cardiology. 1992 Oct 1;70(9):859-862.

Heart Failure / Left Ventricular Dysfunction

Effect of Enhanced External Counterpulsation on Clinical Symptoms, Quality of Life, 6-Minute Walking Distance, and Echocardiographic Measurements of Left Ventricular Systolic and Diastolic Function After 35 Days of Treatment and at 1-Year Follow Up in 47 Patients With Chronic Refractory Angina Pectoris Kumar A, Aronow WS, Vadnerkar A, Sidhu P, Mittal S, Kasliwal RR, Trehan N. American Journal of Therapeutics. 2009 Mar/Apr;16(2):116-118.

   

Enhanced External Counterpulsation in Patients with Heart Failure: A Multicenter Feasibility Study Soran O, Fleishman B, Demarco T, Grossman W, Schneider VM, Manzo K, de Lame PA, Feldman AM. Congestive Heart Failure. 2002 Jul-Aug;8(4)204-208, 227.

Acute Coronary Syndrome / Cardiogenic shock

Portable Enhanced External Counterpulsation for Acute Coronary Syndrome and Cardiogenic Shock: A Pilot Study. Cohen J, Grossman W, Michaels AD. Clinical Cardiology. 2007 May;30(5):223-228.

New Sequential External Counterpulsation for the Treatment of Acute Myocardial Infarction. Zheng ZS, Yu LQ, Cai SR, Kambic H, Li TM, Ma H, Chen PZ, Huang BJ, Nose Y. Transactions of the American Society of Artificial Internal Organs. 1984 Nov;8(4):470-477.

Cost Effectiveness / Comparative studies

Enhanced External Counterpulsation for the Treatment of Stable Angina and Heart Failure: A Systematic Review and Economic Analysis. McKenna C, McDaid C, Suekarran S, Hawkins N, Claxton K, Light K, Chester M, Cleland J, Woolacott N, Sculpher M.Health Technology Assessment. 2009 Apr;13(24):iii-iv, ix- xi, 1-90.

Comparison of Patients Undergoing Enhanced External Counterpulsation and Spinal Cord Stimulation for Refractory Angina Pectoris. Bondesson S, Pettersson T, Erdling A, Hallberg IR, Wackenfors A, Edvinsson

L. Coronary Artery Disease. 2008 Dec;19(8):627-634

Comparison of Patients Undergoing Enhanced External Counterpulsation and Percutaneous Coronary Intervention for Stable Angina Pectoris. Holubkov R, Kennard ED, Foris JM, Kelsey SF, Soran O, Williams DO, Holmes Jr. DR. American Journal of Cardiology. 2002 May 15;89:1182-1186.

Comparison of Hemodynamic Effects of Enhanced External Counterpulsation and Intra-Aortic Balloon Pumping in Patients with Acute Myocardial Infarction. Taguchi I, Ogawa K, Oida A, Abe S, Kaneko N, Sakio H. American Journal of Cardiology. 2000 Nov 15;86(10):1139-1141.

One Year Durability of Enhanced External Counterpulsation Benefit in Improving Quality of Life and Reducing Health Care Costs. Lawson WE, Kennard ED, Linnemeier G, Hui JCK. Presented at the 2009 AHA Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke Conference in Washington D.C., April 23-25, 2009.

Mechanisms of Actions

Hemodynamics

Invasive Left Ventricular Energetics During Enhanced External Counterpulsation. Michaels AD, Tacy T, Teitel D, Shapiro M, Grossman W. American Journal of Therapeutics. 2009;16:239-246. Jan 13. [Epub ahead of print].

Left Ventricular Systolic Unloading and Augmentation of Intracoronary Pressure and Doppler Flow During Enhanced External Counterpulsation. Michaels AD, Accad M, Ports TA, Grossman W. Circulation. 2002 Sep 3;106(10):1237-1242.

Acute and Chronic Hemodynamic Effects of Enhanced External Counterpulsation in Patients with Angina Pectoris. Arora RR, Carlucci ML, Malone AM, Baron NV. Journal of Investigative Medicine. 2001 Nov;49(6):500-504.

   

Acute Hemodynamic Effects and Angina Improvement with Enhanced External Counterpulsation Stys T, Lawson WE, Hui JCK, Lang G, Liuzzo J, Cohn PF. Angiology. 2001 Oct;52(10):653-658.

Pneumatic External Counterpulsation: A New Noninvasive Method to Improve Organ Perfusion

Werner D, Schneider M, Weise M, Nonnast-Daniel B, Daniel WG. American Journal of Cardiology. 1999 Oct 15;84(8):950-952.

Endothelial function

Long-term Effect of Enhanced External Counterpulsation on Endothelial Function in the Patients with Intractable Angina. Hashemi M, Hoseinbalam M, Khazaei M. Heart Lung Circulation. 2008 Aug 13. [Epub ahead of print].

Successful Treatment of Symptomatic Coronary Endothelial Dysfunction with Enhanced External Counterpulsation. Bonetti PO, Gadasalli SN, Lerman A, Barsness GW. Mayo Clinic Proceedings. 2004 May;79(5):690-692.

Enhanced External Counterpulsation Improves Endothelial Function in Patients with Symptomatic Coronary Artery Disease. Bonetti PO, Barsness GW, Keelan PC, Schnell TI, Pumper GM, Kuvin JT, Schnall RP, Holmes DR, Higano ST, Lerman A. Journal of the American College of Cardiology. 2003 May 21;41(10):1761-1768.

Peripheral Endothelial Function is a Primary Clinical Target for Enhanced External Counterpulsation in Patients With Refractory Angina. Braith RW, Casey DP, Beck DT, Nichols WW, Choi CY, Khuddus MA, Conti CR. Journal of the American College of Cardiology.2009 Mar:53(10 Suppl A); (1054-276).

Vasodilatation/Arterial Stiffness / Blood Pressure

Enhanced External Counterpulsation Improves Systolic Blood Pressure in Patients with Refractory Angina Campbell AR, Satran D, Zenovich AG, Campbell KM, Espel JC, Arndt TL, Poulose AK, Boisjolie CR, Juusola K, Bart BA, Henry TD. American Heart Journal. 2008 Dec;156(6):1217-22. Epub 2008 Oct 5.

Enhanced External Counterpulsation Treatment Improves Arterial Wall Properties and Wave Reflection Characteristics in Patients With Refractory Angina. Nichols WW, Estrada JC, Braith RW, Owens K, Conti CR. Journal of the American College of Cardiology. 2006 Sep 19;48(6):1209-1215. Epub 2006 Aug 25.

Enhanced External Counterpulsation Improves Endothelium-Dependent Vasorelaxation in the Carotid Arteries of Hypercholesterolemic Pigs. Tao J, Tu C, Yang Z, Zhang Y, Chung XL, Ma H, Zhen ZS International Journal of Cardiology. 2005 Nov 23; [Epub ahead of print]

Neurohormonal Activation

Cyclic GMP Release by Acute Enhanced External Counterpulsation. Levenson J, Pernollet MG, Iliou MC, Devynck MA, Simon A. American Journal Hypertension. 2006 Aug;19(8):867-872.

Effect of External Counterpulsation on Plasma Nitric Oxide and Endothelin-1 Levels. Akhtar M, Wu GF, Du ZM, Zheng ZS, Michaels AD. American Journal Cardiology.2006 Jul 1;98(1):28-30. Epub 2006 May 3.

Effects of Enhanced External Counterpulsation on Hemodynamics and its Mechanism-Relation to Neurohormonal Factors. Taguchi I, Ogawa K, Kanaya T, Matsuda R, Kuga H, Nakatsugawa M. Circulation Journal. 2004 Nov;68(11):1030-1034.

Effects of Enhanced External Counterpulsation on Rennin-Angiotensin System on Experimental AMI

Lu L, Zheng ZS, Wu WK, Lawson WE, Hui JCK. Proceedings of the 2nd International Congress on Heart Disease – New Trends in Research, Diagnosis and Treatment (International Academy of Cardiology).

2001 Jul 21-24;(Washington DC, USA):275-279.

   

Angiogenesis / Collateral Circulations

Improvement of fractional flow reserve and collateral flow by treatment with external counterpulsation (Art.Net.-2 Trial). E E Buschmann, W Utz, N Pagonas, J Schulz-Menger, A Busjahn, J Monti,W Maerz, F le Noble, LThierfelder, R Dietz, V Klauss, M Gross and I R Buschmann, on behalf of the Arteriogenesis Network (Art. Net).. Eur J Clin Invest 2009. DOI: 10.1111/j.1365-2362.2009.02192.x

Assessment of the effect of external counterpulsation on myocardial adaptive arteriogenesis by invasive functional measurements — design of the arteriogenesis network trial 2. Nikolaos Pagonas, Wolfgang Utz, Jeanette Schulz-Menger, Andreas Busjahn, Jan Monti, Ludwig Thierfelder, Rainer Dietz, Volker Klauss, Michael Gross, Ivo R. Buschmann, Eva-Elina Buschmann and on behalf of the Arteriogenesis Network (Art.Net.). International J of Cardiology 2009:12087.

Angiogenic Effects of Long-term Enhanced External Counterpulsation in a Dog Model of Myocardial Infarction. Wu G, Du Z, Hu C, Zheng Z, Zhan C, Ma H, Fang D, Ahmed KT, Laham RJ, Hui JC, Lawson WE. American Journal of Physiology – Heart and Circulatory Physiology. 2006 Jan;290(1):H248-54.

Epub 2005 Aug 19.

Promotion of Coronary Collateral Growth by External Counterpulsation in Patients with Coronary Artery Disease Gloekler S, de Marchi SF, Rutz T, Meier P, Wustmann K, Rimoldi SF, Togni M, Seiler C. Journal of the American College of Cardiology.2009 Mar:53(10 Suppl A);(1050-126).

Anti-inflammatory

Enhanced External Counterpulsation Promotes Growth Cytokines-mediated Myocardial Angiogenesis in a Porcine Model of Hypercholesterolemia. Luo JY, Wu GF, Xiong Y, Chen GW, Xie Q, Yang DY, He XH, Zhang Y, Liu DH, Wang KJ, Ma H, Zheng ZS, DU ZM. Chinese Medical Journal (Engl). 2009 May 20;122(10):1188-94.

Effect of Enhanced External Counterpulsation on Inflammatory Cytokines and Adhesion Molecules in Patients with Angina Pectoris and Angiographic Coronary Artery Disease. Casey DP, Conti CR, Nichols WW, Choi CY, Khuddus MA, Braith RW. American Journal of Cardiology. 2008 Feb 1;101(3):300-302. Epub 2007 Dec 11.

Circulation Progenitor cell

The Effects of External Counter Pulsation Therapy on Circulating Endothelial Progenitor Cells in Patients with Angina Pectoris. Barsheshet A, Hod H, Shechter M, Sharabani-Yosef O, Rosenthal E, Barbash IM, Matetzky S, Tal R, Bentancur AG, Sela BA, Nagler A, Leor J. Cardiology. 2008;110(3):160-166. Epub 2007 Dec 4.

Circulating Progenitor Cells and Erythropoietin Levels in Patients Undergoing Enhanced External Counterpulsation. Boison B, Kiernan TJ, Tesmer LJ, Harbuzariu A, Kleppe LS, Simari RD, Barsness GW. Journal of the American College of Cardiology. 2008 Mar 11;51(Supplement A)10:A230 (1031-67).

Remodeling / Inhibit intimal hyperplasia

Echocardiographic Characteristics Including Tissue Doppler Imaging After Enhanced External Counterpulsation Therapy. Estahbanaty G, Samiei N, Maleki M, Noohi F, Mohebi A, Ojaghi Z, Esmaeilzadeh M, Sadeghpour A, Soran O. The American Heart Hospital Journal. 2007 Fall;5(4):241-246.

   

Enhanced External Counterpulsation Inhibits Intimal Hyperplasia by Modifying Shear Stress Responsive Gene Expression in Hypercholesterolemic Pigs. Zhang Y, He X, Chen X, Ma H, Liu D, Luo J, Du Z, Jin Y, Xiong Y, He J, Fang D, Wang K, Lawson WE, Hui JC, Zheng Z, Wu G. Circulation. 2007 Jul 31;116(5):526-534. Epub 2007 Jul 9.

Enhanced External Counterpulsation Improves Systolic Function by Echocardiography in Patients with Coronary Artery Disease. Arora RR, Lopez S, Saric M. Heart Lung. 2005 Mar-Apr;34(2):122-125.

Effect of Enhanced External Counterpulsation on Dobutamine-induced Left Ventricular Wall Motion Abnormalities in Severe Chronic Angina Pectoris. Bagger JP, Hall RJ, Koutroulis G, Nihoyannopoulos P. American Journal of Cardiology. 2004 Feb 15;93(4):465-467.

Electrophysiology

The Effects of Enhanced External Counterpulsation on Time- and Frequency-Domain Measures of Heart Rate Variability. Michaels AD, Bart BA, Pinto T, Lafferty J, Fung G, Kennard ED. Journal of Electrocardiology. 2007 Nov-Dec;40(6):515-521. Epub 2007 May 29.

Enhanced External Counterpulsation Therapy: Significant Clinical Improvement without Electrophysiologic Remodeling. Henrickson CA, Chandra-Strobos N. Annals of Noninvasive Electrocardiology. 2004 Jul;9(3):265-269.

Patients Selection / Dosage

Primer: Practical Approach to the Selection of Patients for and Application of EECP. Michaels AD, McCullough PA, Soran OZ, Lawson WE, Barsness GW, Henry TD, Linnemeier G, Ochoa A, Kelsey SF, Kennard ED. Nature Clinical Practice Cardiovascular Medicine. 2006 Nov;3(11):623-632.

Enhanced External Counterpulsation for Chronic Myocardial Ischemia. Lawson WE, Hui JCK. The Journal of Critical Illness. 2000 Nov;15(11):629-636.

A Modified Course of Enhanced External Counterpulsation Improved Myocardial Perfusion and Function in Severe Ischemic Cardiomyopathy Patients. Nayar PG, Ramasamy S, Sankar MN, et al. Journal of Cardiac Failure. 2008 Aug;14(6 Suppl 1):S106(346)

Review Papers

Treatment Options for Refractory Angina Pectoris: Enhanced External Counterpulsation Therapy Soran O. Current Treatment Options Cardiovascular Medicine. 2009 Feb;11(1):54-60.

Enhanced External Counterpulsation and Future Directions: Step Beyond Medical Management for patients with Angina and Heart Failure. Manchanda A, Soran O. Journal of the American College of Cardiology. 2007 Oct 16;50(16):1523-1531. Epub 2007 Oct 1.

Mechanisms and Evidence for the Role of Enhanced External Counterpulsation in Heart Failure Management Silver MA. Current Heart Failure Reports. 2006 Apr;3(1):25-32.

An Update on Enhanced External Counterpulsation. Shea ML, Conti CR, Arora RR. Clinical Cardiology.

2005 Mar;28(3):115-118.

Enhanced External Counterpulsation in Ischemic Heart Disease and Congestive Heart Failure Mielniczuk L, da Silva LB, Haddad H. Canadian Medical Association Journal. 2004 Apr 13;170(8):1223- 1224.

   

Enhanced External Counterpulsation for Ischemic Heart Disease: What’s Behind the Curtain? Bonetti PO, Holmes DR Jr, Lerman A, Barsness GW. Journal of the American College of Cardiology. 2003 Jun 4;41(11):1918-1925.

A Historical Overview of Enhanced External Counterpulsation. DeMaria AN. Clinical Cardiology. 2002 Dec;25(12 Suppl 2):II3-5.

A Review of Enhanced External Counterpulsation Clinical Trials. Beller GA.Clinical Cardiology. 2002 Dec;25(12 Suppl 2):II6-10.

Enhanced External Counterpulsation: Mechanism of Action. Feldman AM. Clinical Cardiology. 2002 Dec;25(12 Suppl 2):II11-15.

Current Use of Enhanced External Counterpulsation and Patient Selection. Lawson WE. Clinical Cardiology. 2002 Dec;25(12 Suppl 2):II16-21.

Treatment Options for Angina Pectoris and the Future Role of Enhanced External Counterpulsation. Holmes DR Jr. Clinical Cardiology. 2002 Dec;25(12 Suppl 2):II22-25.

Ongoing and Planned Studies of Enhanced External Counterpulsation. Conti CR. Clinical Cardiology. 2002 Dec;25(12 Suppl 2):II26-28.

Enhanced External Counterpulsation - A Therapeutic Option for Patients with Chronic Cardiovascular Problems. Linnemeier G. Journal of Cardiovascular Management. 2002 Nov-Dec;13(6):20-25.

Experience with Enhanced External Counterpulsation (EECP) in Coronary Artery Disease. Crawford LE.

Today’s Therapeutic Trends. 2002;20(3):243-252.

Noninvasive Revascularization by Enhanced External Counterpulsation: A Case Study and Literature Review. Singh M, Holmes Jr. DR, Tajik AJ, Barsness GW. Mayo Clinic Proceedings. 2000 Sep;75(9):961- 965.

Enhanced External Counterpulsation in the Management of Patients with Cardiovascular Disease Soran O, Crawford LE, Schneider VM, Feldman AM. Clinical Cardiology. 1999 Mar;22(3):173-178.

Historical Review of the Development of Enhanced External Counterpulsation Technology and its Physiologic Rationale. Soroff HS, Hui JCK, Giron F. Cardiovascular Reviews and Reports. 1997 Nov;18(11):34-36, 39.

Others

Carotid Circulation

Effects of Enhanced External Counterpulsation on Carotid Circulation in Patients with Coronary Artery Disease. Levenson J, Simon A, Megnien JL, Chironi G, Gariepy J, Pernollet MG, Craiem D, Iliou MC. Cardiology. 2007;108(2):104-110. Epub 2006 Sep 29.

Enhanced External Counterpulsation Does Not Compromise Cerebral Autoregulation. Marthol H, Werner D, Brown CM, Hecht M, Daniel WG, Hilz MJ. Acta Neurologica Scandinavica. 2005 Jan;111(1):34-41.

Changes of Cerebral Blood Flow Velocities During Enhanced External Counterpulsation. Werner D, Marthol H, Brown CM, Daniel WG, Hilz MJ. Acta Neurologica Scandinavica. 2003 Jun;107(6):405-411.

  

Peripheral Circulation / Retinal Circulation / Skin Perfusion

Impact of Enhanced External Counterpulsation on Peripheral Circulation. Werner D, Michalk F, Hinz B, Werner U, Voigt JU, Daniel WG. Angiology. 2007 Apr-May;58(2):185-190.

Accelerated Reperfusion of Poorly Perfused Retinal Areas in Central Retinal Artery Occlusion and Branch Retinal Artery Occlusion After a Short Treatment with Enhanced External Counterpulsation. Werner D, Michalk F, Harazny J, Hugo C, Daniel WG, Michelson G. Retina. 2004 Aug;24(4):541-547.

Enhanced External Counterpulsation Improves Skin Oxygenation and Perfusion. Hilz MJ, Werner D, Marthol H, Flachskampf FA, Daniel WG. European Journal of Clinical Investigation. 2004 Jun;34(6):385- 391.

Changes in Ocular Blood Flow Velocities During External Counterpulsation in Healthy Volunteers and Patients with Atherosclerosis. Werner D, Michelson G, Harazny J, Michalk F, Voigt JU, Daniel WG. Graefe’s Archive for Clinical and Experimental Ophthalmology. 2001 Aug;239(8):599-602.

Liver / Renal

Enhanced External Counterpulsation: A New Technique to Augment Renal Function in Liver Cirrhosis Werner D, Trägner P, Wawer A, Porst H, Werner DG, Gross P. Nephrology Dialysis Transplantation. 2005 Mar 23; [Epub ahead of print].

Erectile Dysfunction

Enhanced External Counterpulsation in Patients with Coronary Artery Disease-Associated Erectile Dysfunction. Part I: Effects of Risk Factors. El-Sakka A, Morsy A, Fagih B. Journal of Sexual Medicine. 2007 May;4(3):771-779. Epub 2007 Apr 13.

Enhanced External Counterpulsation In Patients With Coronary Artery Disease-Associated Erectile Dysfunction. Part II: Impact Of Disease Duration And Treatment Courses. El-Sakka AI, Morsy AM, Fagih BI. The Journal of Sexual Medicine. 2007 Jul 18;4(5):448–1453. [Epub ahead of print].

Effect of Enhanced External Counterpulsation on Medically Refractory Angina Patients with Erectile Dysfunction. Lawson WE, Hui JC, Kennard ED, Soran O, McCullough PA, Kelsey SF; for the IEPR Investigators. International Journal of Clinical Practice. 2007 May;61(5):757-762.

Enhanced External Counterpulsation as a New Treatment Modality for Patients with Erectile Dysfunction. Froschermaier SE, Werner D, Leike S, Schneider M, Waltenberger J, Daniel WG, Wirth MP.

Urologia Internationalis. 1998;61(3):168-171.

Restless Legs Syndrome

Enhanced External Counter Pulsation (EECP) as a Novel Treatment for Restless Legs Syndrome (RLS): A Preliminary Test of the Vascular Neurologic Hypothesis for RLS. Rajaram SS, Shanahan J, Ash C, Walters AS, Weisfogel G. Sleep Medicine. 2005 Mar;6(2):101-106. Epub 2005 Jan 24



Learn More

If you have one of these conditions just click on the link to go the the source and  call us  425-770-9466 remember to click back here.